Dr. Anthony Chaffee provides an in-depth analysis of ApoB cholesterol testing and its limitations in predicting cardiovascular disease. He reveals that no randomized controlled trial in human history has ever demonstrated a cause-and-effect relationship between any form of cholesterol and heart disease. The episode explores how glycation damage from elevated blood sugar actually knocks ApoB molecules off LDL particles, creating misleading test results that cannot distinguish between damaged and healthy cholesterol markers.
The discussion expands to examine the Kraft Test, a comprehensive glucose tolerance assessment that identified metabolic dysfunction in 100% of cardiovascular disease patients among 30,000 subjects studied. Dr. Anthony Chaffee contrasts this with the flawed observational studies like the Nurses' Health Study, which rely on unreliable food questionnaires, while highlighting superior observational data comparing the carnivorous Maasai tribe to their plant-based neighbors, showing dramatic differences in health outcomes including height, dental health, and chronic disease prevalence.
Key Takeaways
ApoB testing cannot distinguish between damaged cholesterol particles (caused by blood sugar glycation) and healthy LDL molecules, making it an unreliable marker for cardiovascular risk assessment
The Kraft Test using oral glucose tolerance with insulin measurements identified metabolic dysfunction in 100% of cardiovascular disease patients out of nearly 30,000 subjects, while those with normal glucose-insulin responses had no atherosclerosis
Five large-scale randomized controlled trials showed that replacing animal fats with vegetable oils either provided no cardiovascular benefit or actually increased deaths from heart attacks and strokes
Real-world observational data from the 1920s British study showed the carnivorous Maasai were five inches taller with perfect dental health compared to their genetically similar plant-based neighbors who suffered multiple chronic diseases and nutritional deficiencies
ApoB and Cholesterol Testing - Why Current Tests Are Flawed
The Craft Test and Glucose Damage - Real Causes of Heart Disease
Cholesterol Studies Debunked - No Evidence for Heart Disease Link
Crisco and Heart Healthy Oils Lie - Industrial Origins of Bad Nutrition
Food Questionnaire Studies vs Real Observational Data
This is an auto-generated transcript from YouTube and may contain errors or inaccuracies.
[Music] What's your take on on on Apo B? No, >> I look look there there have never in the entire history of human existence ever been a experimental trial that was capable of showing a cause and effect relationship like a randomized control trial that has ever shown a cause and effect relationship between any form of cholesterol and cardiovascular disease. None. not a B, not total cholesterol, not LDL, not SDLDL, not any of the different subfractions of uh LDL, nothing. And so you cannot say that there's a cause and effect relationship between these things. Um, apple B changes for all sorts of different reasons. Apple B 100 is is a um signaling molecule on LDL that that the liver recognizes so it can draw it back into the liver. So if you get it damaged through glycation which is elevated blood sugar because again elevated blood sugar is toxic to the human body which is what kills diabetics and this damages LDL cholesterol and this knocks off that apple B 100. So now you have free appleo B flo floating around. Okay so free appleo B flo floating around is that bad? Yeah of course it is. Is that because apple causes atherosclerosis and heart disease? Not necessarily. It's there's a glycation damaging process that's going on. you're you're glycating and damaging these LDL molecules and you're knocking off Appo B, right? But you the blood test that we have actually cannot distinguish between the apple that's been knocked off and damaged and free floating and the apple B that's stuck onto a healthy large buoyant fluffy LDL molecule that's perfectly normal and fine. So as your LDL goes up, your apple B is going to go up, you know, and it has has nothing to do with saturated fat. Saturated fat again has nothing to do with uh serum levels of cholesterol or apo you know that's that's actually well established you know and even accepted again US dietary recommendations you know they they they cite data showing that they're like look there there's no reason to limit saturated fat because it has absolutely no bearing on serum cholesterol absolutely no bearing on cardiovascular disease except in a protective role as we saw from you know Jack the journal American College of Cardiology. So, Applebe B is is a very poor test because you you don't know what you're looking at. It's also really just smoke. It's not the fire, right? Because it's if you do have free floating apple B, it's because it's been knocked off through glycation. It's glycation that's the problem. There's a guy named Dr. Craft who developed the Craft test, which is a oral glucose tolerance test with insulin looking at, you know, multiple times. So you know at at you know you know time zero two hours you can check it at five hours as well and you see how your body re responds not only to that insult of glucose but also how does your insulin respond and do you have a you know an appropriate insulin response and does your glucose correspondingly go down when your insulin goes up. are you insulin sensitive? And um and and you see this so so Craft, it was back in the 60s, he looked at something something close to like 30,000 patients and he and he did this for all of his massive massive piece of work. And he found that there were only five patterns that emerged of of how your body responds to glucose and insulin given this period of time and this test. and that he found that very early on your body can start responding inappropriately to both glucose and insulin showing that there's some sort of metabolic dysfunction. So, early diabetes, pre-diabetes, whatever you want to call it, full-on diabetes, whatever, there's some sort of glucose and insulin um issue and mismatch, and your body's just not able to metabolize these things properly. So, if you call that point the point that diabetes is starting, call it pre-diabetes or whatever, but that's a point that it's starting starting to manifest. you're seeing this on on these blood tests and on the craft uh O GTT that 100% of the people in that group out of nearly 30,000 people who had cardiovascular disease had that dysfunction and early diabetes. And none of the people who uh didn't have that derangement in blood sugar and insulin had atheroscerosis or cardiovascular disease basically. So it's the damage from the glucose that is damaging your vessels causing damage causing that those those that lining to be damaged and causing that to to form clots and damage and build up aththeroscerosis and plaques and scarring because that's trying to heal. It's healing damage. There wasn't damage in the first place. There wouldn't need to be any healing and you wouldn't need to build up any plaques. Um other things can damage your the lining. Nicotine directly damages the artery linings which is why you know smoking and any nicotine product is a risk for developing atheroscerosis and peripheral vascular disease. Um homocyine is also known to damage the the artery lining and that is an amino acid that is metabolized by B12. If you don't have enough B12 then you won't metabolize homoyine properly. you get high levels of homocyine and you start damaging your arteries. So there's all these different sorts of things. So you know the thing with with cholesterol again there has never been a highle experimental study that has ever shown a cause and effect relationship between any form of cholesterol and cardiovascular disease. And yet there have been at least five large-scale randomized control trials in humans with thousands of human subjects that have shown the opposite. that replacing animal fats with vegetable oils, a polyunsaturated so-called heart-healthy fats and lowering cholesterol either had no benefit whatsoever to cardiovascular disease or cause more deaths from heart attacks and strokes, right? So, what the hell are we doing here? Why aren't we teaching those those in medical school? If there was robust data to show that cholesterol caused heart disease, why don't we use it? Why are we using observational studies like the Framingham study that said, "Oh, there's observation over time that people had higher levels of cholesterol had higher levels of cardiovascular disease." Well, that's what was taught to me in medical school. That's what's taught to most people in medical school. And we just take it at face value. Oh, okay. I guess yeah. Well, everyone knows cholesterol causes heart disease. That doesn't show a cause and effect relationship. That's that's an association. Associations cannot by definition and terms show a cause and effect relationship. You cannot that's definitional. And so and the other the other side of it is too is that the actual framing it was actually misrepresented. The original data showed the opposite. Showed actually lowering cholesterol actually increased death from cardiovascular disease. And it was misrepresented by the American Heart Association who again is in the published literature and in just in newspapers having taken been taking bribes from sugar companies and Proctor and Gamble and other sorts of industries for years to push forward whatever the hell they want. Proctor and Gamble made a product called Krisco. Krisco is hydrogenated vegetable oil. And vegetable oil is an industrial product product that was used in the industrial revolution. And hydrogenating this made a thicker more viscous oil that was used to lubricate big heavy machinery like tanks and submarines in the German army. The German army actually developed hydrogenation of vegetable oil and and made this product. And Proctor and Gamble bought that technology from the German military in 1911 and then put this product out and just started feeding it to people and calling it Krisco. And they paid Proctor and Gamble the equivalent of $20 million to lie and say that Crisco was good for your heart and that butter and lard were bad for your heart. This is the origins of the good fats and bad fats and heart healthy plant oils and bad for your heart, you know, animal fats. It's it's lie. It's a complete lie. It's published. It's well documented and yet we're still calling this heart healthy fat. No, of course it's not. It kills people. You know, I mean that that's what the randomized control trials say. And people, well, that's these things are flawed because of this. Name one randomized control trial in humans showing that replacing animal fat with so-called hearthealthy vegetable oil and lowering LDL and total cholesterol and appo by the way that would have gone down too in in those studies shows a cause and effect relationship between cholesterol and heart disease. There are none. None exist on this earth. If there were, they'd be talking about it. There are none. Has anybody ever said any to you? No. because there are none, you know, there there there's absolutely none. So, they talk about these observational studies, they talk about the nurses study, which is like they give these people like a food questionnaire once a year and say, "Hey, what did you eat last year?" Like, what the hell are you talking about? What I ate last year? You remember every single meal ever eaten? Like, give me a break. You know, if they were serious about this, they'd say, "Hey, here's a here's a log. Keep track of all the meals you've had you're going to have this year." if they were serious about this, which they're not, they want to be able to have garbage data that they can manipulate to look any way they want because, well, we we were going to correct for this because of course they have incomplete data. What does incomplete data mean? It means it's garbage. It's no good, right? So, they they correct for things and they adjust for things. They they lie and make things up basically. And they say and they manipulate that data in any way they want. they correct it, meaning that they manipulate the data, they change the data, they change the outcomes to fit anything that they want. And now maybe they do that in an honest way, but maybe they don't. And either way, they're manipulating the data. They're changing it. And the fact of the matter is the people that do this, like Professor Walter Willlet at Harvard, they're vegan activists. They're open vegan activists. And so, of course, they're biased. Of course, they're not going to do this in a in an unbiased sort of way. and and it's and it's rife for bias because it's it's you know it's a garbage way of collecting um data and so they're saying well no this is this this shows such good no it doesn't it's garbage it's not even good observational data like if you go and you go to the Messiah in in you know in in um Tanzania and and Kenya and you see that they are the tallest human beings alive on earth they're extremely healthy they don't get any of these diseases you know modern um diseases of civilization. They only eat, you know, blood, meat, and milk. And they're crazy healthy, perfect teeth, bleach white, you know, they don't have dentists or orthodontists or anything like that. They're fabulously healthy. And then their neighbors, the Yakuyu, who are alive at the same time in the same area, they interbreed, so they're genetically similar, and they're largely plant-based, whole food, plant-based, grow their own stuff, right? no pesticides or anything. And the Akuyu, who are of genetically the same stock, five inches shorter, smaller brains, smaller jaws, crooked teeth, poor dentition, multiple health issues, many chronic diseases, and nutritional deficiencies. And even when you correct those nutritional deficiencies, they don't actually improve their health. It's only when you replace the plants they're eating with meat that they actually get better. That was a large-scale observational study done by the British in the 1920s and that was published in 1931. It was 170 pages long. Hey guys, just want to take a second to thank our sponsor at Carnivore Bar. I don't promote many products because honestly all you need to be healthy is to just eat meat. For those times that you're out hiking, road tripping, or stuck at work and you want nutritious snack that is just meat, fat, and salt if you want it. The Carnivore Bar is a great option. So, I like this product not because it's just pure meat, but also because I want the carnivore market to thrive as well. And the more we support meat only products, the more meatonly products there will be available in the mainstream. So, if this sounds like something you'd like to get behind, check it out using my discount code Anthony to get 10% off, which also applies to subscriptions, giving you 25% off total. All right, thanks guys. So, what about that study? That's a real observational study where they're they're looking at very specific things going on. They're not cherry-picking thing and correcting the data and fudging things and saying, "Hey, you know, why don't you fill this out and just tell me this and send it back." There are levels and of quality for observational studies. And the nurses trial and these these um food frequency questionnaires, which is what they're called, are garbage. They're just complete and utter garbage. And they can be manipulated and changed in so many different ways. You could do them fairly well, but this is not a good example of that. But you have other observational studies that are far better. You have, you know, people say that, well, the data about the fossil record about, you know, how humans have been, you know, eating for millions of years, that's observation. Well, no, not really because, you know, we have have scientific, you know, um, information looking at at the stable isotope um, picture where we can actually tell what animals were eating at certain times and, you know, what if they were, you know, had had different sort of levels of um, of carnivory. they were eating more animals or less, you know, animals or more plants or actually eating animals that ate animals that ate animals that ate plants or just eating animals that ate plants for instance, higher up on the food chain for, you know, for example, you know, you can actually tell that through through scientific endeavor. And and um so that's not the same as like handing out a flyer and saying, "Hey, can you remember every meal that you ate in the last two years?" >> You know, completely different things. And either way, it's observational. The only experimental data shows that cholesterol is absolutely not a problem. The only experimental data shows that saturated fat is not a problem and in fact is beneficial in a number of different ways. It just is flat out against the literature and against well-known scientific um experiments in another way like they did in the supernova trial where they took ketogenic athletes and they said, "Okay, you go or they took athletes and said, "Okay, you drop the carbs, go keto." And but they only gave them two weeks and then they tested them sort of, you know, very quickly after, you know, a couple weeks. Um they also