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15:11 · Aug 04, 2025

How Your Bad & Unhealthy Diet Affects Your Brain ( Surprising Answer! )

Dr. Anthony Chaffee provides insights into brain health and cancer metabolism based on his neurosurgical experience. He explains how dietary changes since the 1980s correlate with a tripling of cancer rates, obesity, and other chronic diseases, supporting the theory that cancer is primarily a metabolic disease rather than genetic. The discussion reveals how damaged mitochondria in cancer cells revert to primitive fermentation processes, requiring 400 times more glucose than healthy cells.

The episode explores groundbreaking research by Thomas Seyfried showing that ketogenic and carnivore diets can effectively starve cancer cells by limiting glucose while supporting healthy cellular function through ketones. Dr. Anthony Chaffee shares remarkable cases of glioblastoma multiforme patients surviving 6-8 years on metabolic approaches, compared to the typical 15-month survival with conventional treatment. He also details his personal eating approach, focusing primarily on skeletal muscle meat and fat while questioning the necessity of organ consumption.

Key Takeaways

  • Cancer cells require 400 times more glucose than healthy cells due to damaged mitochondria that can only use fermentation, making ketogenic and carnivore diets effective at starving tumors while supporting normal cellular function
  • Glioblastoma multiforme patients using metabolic approaches have survived 6-8 years without chemotherapy or radiation, compared to the standard 15-month survival rate with conventional treatment
  • Since the 1980s dietary guidelines vilifying meat and promoting plant foods, cancer rates have tripled alongside obesity, heart disease, and autoimmune disorders - changes too rapid to be genetic
  • Skeletal muscle meat and fat provide complete nutrition without requiring organ consumption, as evidenced by populations like the Inuit who avoided toxic organ meats and traditional practices of giving organs to dogs while humans consumed fatty cuts
  • Brain Health and the Maillard Reaction in Disease
  • Glioblastoma and Metabolic Cancer Treatment
  • Diet Changes Since 1980s and Cancer Rate Explosion
  • Mitochondrial Damage and Cancer as Metabolic Disease
  • 8-Year Glioblastoma Survival Stories on Carnivore Diet
  • Personal Carnivore Diet and Why Organ Meats Aren't Necessary

This is an auto-generated transcript from YouTube and may contain errors or inaccuracies.

Generally, when you're when you're looking at unhealthy brain, you you have like a bleed or compression. It's bruised and it's disease and there's like a tumor under there. That's that's when you'll see distinctive uh visual uh differences. But you actually see uh uh actual browning of the bone and older people or sick people and browning of of the of uh you know the brain as well. It's called the myard um reaction where you're actually like you know glycating. Yeah. and glycating and you know oxidizing like these these different things like when when you cook and you brown something it browns it that's that's may myard uh reaction and we actually do this to ourselves. So you have you have someone who has uh who who hasn't really been taking care of themselves, you know, or someone who's who's like a kid, bone is like bright white, you know, it's clean, it's white, it's it's pristine, you're like, that's a healthy looking bone. >> And then you get someone who's older, they've been smoking and drinking and and not really taking care of those. That's actually brown. You know, the bone itself is brown and yellowed. And so you can you can certainly see those those sorts of things. Yeah. When you get the body, >> does it smell different as you're cutting into the skull? Can you kind of tell an unhealthy person by just the smell or is it all >> um I haven't really noticed that uh myself but you know probably you you probably could you know um but uh not that I've I've I've known so far but I'll probably I'll take a look for that. It' be interesting to to see but um I think one of the more sort of fatal forms of cancer you know really we were talking about glyopblastoma multififor is that >> multifor yeah or or just GBM >> GBN um you know five five year survival rate is like singledigit percentage right and but what we we talked about Thomas A freed and and other people are using a metabolic approach to to you know sort of ailarate all the issues that that that are associated with that um can you speak to how our metabolism I mean to me it's just fascinating that that you can change your diet and then that improves the the capacity of the body to to recover from this really fatal tumor. >> Yeah. Well, that that's the thing, you know, as Professor Safe would say um you know, if you understand that the cancer biology to it. It's actually, you know, uh uh it's not that that difficult to to imagine that this plays a huge role or even that you know that it it's going to play a huge role because, you know, as he argues and he makes a very very strong case for it is that cancer is actually a metabolic disease. It's not a genetic disease. Goodam a good example of this which I' I've pointed out and noticed is that you know since we made these massive dietary changes in the 1980s we vilified meat and fat and started eating you know we we reduced our fat and intake by 30% cholesterol by 30%. Uh reduced red meat by 33% or so increased fruits and vegetables by 30 and 40% respectively as well as grains and sugar as well. And uh you know since then you know all these different diseases so-called chronic diseases have increased. You know, the obesity rate tripled, heart disease tripled, stroke rate tripled, cancer rates have tripled, type two diabetes, autoimmune disorders, Alzheimer's, Parkinson's, even neurode developmental delays such as autism have all increased exponentially. They almost didn't exist before then. Now they're the only things we treat. Um, so that's not genetic, you know, and they all increase at the same time, you know, and so that's very suspicious, you know, and I I you know, I would bet that you, you know, you would say that this this is very likely to be diet related. Uh, but it is something something happened in our environment. You know, you you as a population, you anyone who study population genetics, you know that you cannot change a population's genetics like that in that short of time, even you know, even even a number of generations. I mean you need hundreds or thousands of generations to do something that dramatic genetically. Um so something in our environment and um so that means that something in our environment has affected our cancer rates because our cancer rates have tripled. So it's not purely genetic is it? You know maybe we're just getting exposed to so many more carcinogens that destroy our genetics maybe. But I you know no one's really you know shown that we've been doing it. We're getting less sun than we ever have. you know, we're very conscious about, you know, uh, what we eat in the wrong direction, I'd say. You know, we're we're smoking less, we're, you know, drinking less, all these sorts of things. You know, people are much more conscious about and they're still getting these things. So, Dr. Seaff Freed uh argues that this is this is really a disruption of our mitochondria. This is from a metabolic issue. We do know that people who go on a ketogenic diet, who just are in ketosis, their mitochondria are more healthy. They have they're better at oxidative for phosphorilization and they uh have more number. So they're they have like four times the number and they're like four times as effective. So they're much much better. They're giving you much better energy. Um when you get damaged mitochondria and they stop being able to go through oxidative phosphorilization, they go back to one of our primitive uh modes of energy generation, you know, when when life was still a single cellled organism, which was fermentation. And so they start fermenting glucose and so they need a lot more glucose because it's not as efficient and they'll start making lactic acid and other byproducts and um and so they'll actually need 400 times the amount of glucose. So you can screw up your mitochondria in a number of different ways. And once they get to that point where they're just they're they're not going back and they're only fermenting then you know you you can you can get pretty screwed because it's the mitochondria that actually uh can then kick off reactive oxygen species that then damage your DNA. So he argues that this is actually an epi effect an epi phenomenon of the damaged mitochondria not that they started the the genetics started it and then the rest happened that it was the mitochondria first and then um which we see you in tumors like it's not just all the cells don't just have the same genes they they're they're all different you know and a lot of them have normal DNA and they act like cancer the mitochondria are all screwed the mitochondria are the gatekeeper the mitochondria are what stop the cell from proliferating getting out of control, which is what cancer is. So, when you get those damaged and screwed up, you know, then you're getting uh you're going to be precipitating cancer. But when you go back on a carniv keto diet or a carnivore diet, you are now severely limiting the food supply of those cancer cells because they need 400 times the amount of glucose to just run, right? And we've known this since like the 1930s with Otto Warberg, who who won the Nobel Prize in in medicine for this research into cancer. And he argued then that this was a metabolic disease driven by the mitochondria. And Seaf Freed has actually proven he has over 150 peer-reviewed papers on the subject. And he's actually showed that Warberg was right. There's actually more to it than that because there's glutamine, which is the most abundant amino acid in the body. This is actually something that cancers feed on as well. So you can take things like Dawn, which is an acronym for a large chemical name that I don't remember at this time at the moment, uh that uh can actually limit the amount of glutamine. this really really works at at suffocating and starving out these cancer cells. So when you go on a keto diet or a carnivore diet, you are really limiting the amount of energy that these cancer cells can get. So they're not going to be able to proliferate as well. Um your body works just fine because your body works on, you know, you're still in normal glucose levels, blood sugar levels, glycogen levels, but also now you have a bunch of ketones. So you're working great. Cancer cells cannot run on ketones because their mitochondria are screwed. And so they get severely limited by this. And your body is much better able to contain and and and kill these little bastards, which is trying to do the whole time. And you're also, you know, not continuing this this metabolic process of screwing up your your mitochondria and your other cells and uh and contributing to the whole problem. And so you know he's shown in animal models that this is very very very effective uh way of treating cancer and there are different uh groups around the country and and around the world they're actually picking this up. Cedar Cyani have actually started doing this and and uh treating people metabolically these metabolic treatments um for cancer. Now it is the rule that you have to exhaust uh traditional therapies first, chemo radiation first before you get to go on to metabolic therapies. But you know if someone just says yeah I'm not doing that crap it's it's their body they get they get to choose it. And so a number of people have he's done a lot of research with uh GBM uh which is the most aggressive form of primary brain tumor and it's you know it's a with treatment without treatment from time of diagnosis is average 3 month life expectancy um with treatment traditional treatment chemotherapy and radiation at the moment the the numbers are about 15 months. There are some new things coming out, new numbers coming out probably looking closer to two years. That's great. But you know, published numbers right now are around 15 to 18 months uh from from time of diagnosis. But you have people that that see free knows and these people have been treating metabolically. They've never taken treatment. They've never taken chemo and radiation. They're still alive eight years down the track. Hey guys, just want to take a second to thank our sponsor Carnivore Bar. I don't promote many products because honestly all you need to be healthy is to just eat meat. For those times that you're out hiking, road tripping, or stuck at work and you want nutritious snack that is just meat, fat, and salt if you want it, the Carnivore bar is a great option. So, I like this product not because it's just pure meat, but also because I want the carnivore market to thrive as well. And the more we support meatonly products, the more meatonly products there will be available in the mainstream. So, if this sounds like something you'd like to get behind, check it out using my discount code, Anthony, to get 10% off, which also applies to subscriptions, giving you 25% off total. All right, thanks, guys. They've had surgery for debulking, >> you know, but being just on a keto, not even like carnivore, like dirty carnivore, sort of, you know, keto sort of thing. They're they're still, you know, being alive and kicking eight years down the track. And I I have a aecdotal obviously, but there's a ton of animal uh models that show that this this is exactly what we're seeing. And um you know, and it's just a matter of of of doing those studies in in people. Uh but I have a friend of mine that I I sort of uh just said, "Hey, here's the research. Here's some information. Take a look at this. I really think this would help you." She was diagnosed with GBM uh about six years ago, and she's still here. you know, she's got uh, you know, husband and kids and and she's she's living a fairly normal life. She at her five-year check MRI, she had no sign of disease, >> which is amazing. I don't know if she stopped being as straight. She was sort of dirty. She would sort of go back and forth, but a lot of it what she was doing was meat and she did sort of take what I was saying to heart. Um, and then sort of at 6 years it it started to come back and so she needed to get like a further debulking. Um, but 6 years is is absolutely unheard of for for a GBM and especially to be, you know, completely functional and uh and home with your kids as well. Yeah, >> that's so cool. I mean, this this should be front page news, you know, but um some people have this perception. We we all have family and friends who would say, well, I could never just go on a carnivore diet, or I could never What about bread? What about cookies? It's like, well, you can eat those foods and you're not going to live as long. amazing the addictive going back to what we were talking about with honey or fruit or fructose. Like we have these uh rituals and habits and you know sort of connection to this food that some people would rather live a shorter lifespan than live without those things. Like it's it's wild. >> Which leads me to a question that I would love to dive further into is you made a you retain a really good physique and you're strong and everything like that. Um what do you currently eat? How many meals a day? Are you tracking protein? you know, is it do you include organs? Like there's all sorts of ways to go about it, you know. Yeah. What's your personal approach? >> Yeah, I I almost exclusively eat just skeletal muscle, meat, and fat. Uh I don't really eat too many organs, mostly through preference, you know, just they're not really what I want. I don't think you need them. I mean, I've been doing this 5 years in my early 20s and the last 5 years now. I've eaten liver twice in the last 5 years. I don't think I ate liver at all before that. And um I you know I I you know I I look at like people like the Inuit who didn't eat the the organ meat certainly didn't eat the liver because the liver of of marine mammals was highly toxic uh for its vitamin A levels, you know. So even just eating a little bit of of polar bear liver will kill you with the amount of vitamin A that it has in there. uh seals are sort of just below that, you know, like there's step up the food chain with the polar bears because the polar bears are eating the seals and so they have they have even more uh vitamin A which stores in your liver is fat soluble. It takes a long time to clear and so they wouldn't eat that at all. They give that to their dogs and you know um I know that that people are proponents of of eating uh organ meat and livers uh and fine they say oh look at wolves you know they you know alpha wolf goes you know directly for the for the liver and all that sort of stuff. Yeah, maybe. But, you know, we're not dogs. We're not wolves. You know, we and and we do know that in in our relationship with dogs and wolves going back thousands and thousands of years, >> traditionally they they got the the organs and we got the meat. You know, Lewis and Clark, you know, the expedition across uh, you know, America, they actually were talking about the same thing. They were hunting, they were eating meat and um and they found that the people that that fat was really really the the survival uh driver. So those who weren't were getting more lean, weren't getting uh enough fat, they were dying. They were dying on this expedition. And so what they were doing is they were giving the lean cuts and they were giving the organs to the dogs that they were with and they were eating going for the fattiest part. And those were the those were the guys who survived. So, I don't I don't think that objectively you need organ organ meat. I don't think you need it. I also don't think that um you need it in in the proportions that some people get because, you know, obviously if you're hunting an animal and you you take down an animal, you have a liver, you know, one liver for Yeah. for hundreds of pounds of of animal meat, you know, and so that's a very very different proportion. So, you know, if I if I, you know, took down a cow and I bought a cow from a butcher, you know, that's going to feed me and my family for like a year or more, it's going to come with one liver, you know, and so eating liver in a in a significant proportion every single day is out of proportion with what I would would uh find if I was just hunting. So the idea of this, oh, they just eat nose totail, isn't actually necessarily true. But even if it is, that's a very specific proportionality. Oh, honey, that's an animal product, right? Well, it's actually, you know, bee vomit and they're just vomiting up concentrated nectar, okay, which comes from a plant. So, if you want to get technical, it goes back and uh, you know, it's not it's not exactly an animal. U, but it's also sugar, okay? So there's more fructose.
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